Department of Biomedical Engineering. Department of Materials Science. In a recent study, the researchers discovered how to pre-program the devices' network . "Current microfluidic technology often requires a desktop full of equipment to operate something the size of a quarter," said Northwestern's Adilson Motter, senior author of the study. Espinosa is a mechanician and nanotechnologist known for his contributions in the areas of deformation and failure of materials, design of micro- and nano-systems, and microfluidics for single cell manipulation and analysis. April 2021: Collaborative work between previous group members Jian Zhang, Won-Kyu Lee, and Dongjoon Rhee and Hangzhou Dianzi (University in China), "Spontaneous Formation of Ordered Magnetic Domains by Patterning Stress . To do this we combine live-cell imaging, microfluidics, and single-cell RNA-Seq to generate a quantitative profile of immune cell behavior. Office location: Tech F222. . While measuring chloride levels in sweat to diagnose cystic fibrosis is standard, the soft, flexible . Research Statement: Working on new reconstruction algorithms to improve the quality of x-ray images and developing instrumentation in x-ray microscopy for mm to cm samples. Now Northwestern University . "In 10 years, this technology, called microfluidics, will be the prevailing technology for biological research." For more information, check out the following video. Content The molecular basis of fluid mechanics. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208 USA. McCormick School of Engineering and Applied Science. EVANSTON - A Northwestern University research team, led by John Rogers, has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise. The result? •Microfluidics has high-throughput, quantitative, and small-scale benefits for engineering, physics, chemistry, biology, materials science, and biotechnology. A multi-layer approach segregates components belonging to two fundamental categories: passive fluidic components (channels and reaction chambers) and active electromechanical control structures (sensors and actuators). Using Microfluidic Devices to Model and Investigate Leaky Gut Syndrome Public Deposited. A skin pH measuring device developed by Northwestern researchers and L'Oréal. 2 To put this in perspective, the average width of a human hair is about 80 microns and the diameter of a hydrogen atom is 0:00005 micron. In a recent study, the researchers discovered how to pre-program the devices' network . As described in detail in Materials and Methods, fabrication of this construct begins with formation of a 2D microfluidic system in PDMS . In this paper, we describe an innovative modular microfluidic platform allowing filtering, concentration and analysis of peptides from a complex mixture. Group: Jacobsen Group. Phone number. Address. Since receiving his Ph.D. he has worked as a senior researcher at MIT, Massachusetts General Hospital, and MC10 Inc. Northwestern Resources. Hunter employed and managed the microfluidic technology, and led the engineering team at NU. S Shiva P Nathamgari PhD, Theoretical and Applied Mechanics, Northwestern University Verified email at u.northwestern.edu. The possibility of coupling such technologies with soft hydrogels and thin, low-modulus microfluidic platforms allows conformal interfaces to the epidermis to facilitate fundamentally differentiated ambulatory modes for biofluid (i.e. northwestern.edu High-Throughput Regulatory Part Prototyping and Analysis by Cell-Free Protein Synthesis and Droplet Microfluidics . Address. A little larger than a quarter and about the same thickness, the simple, low-cost device, described in the journal . However, optical detection methods limit analyses to fluorescent or UV-active compounds and traditional 2D fluidic designs have limited degrees of freedom. A flexible magnetic loop antenna, a set of near-field communication (NFC) components, and a light-emitting diode (LED) as a mode for user notification form a wireless interface to NFC-enabled devices (smartphones, tablets, etc) for transmitting digital identification codes and for reading skin . Microfluidics experience; Benefits: At Northwestern, we are proud to provide meaningful, competitive, high-quality health care plans, retirement benefits, tuition discounts and more! This article describes a microfluidic device that has three inputs and performs 2592 distinct enzyme reactions using only 150 μL of reagent with quantitative characterization. He is pairing SAMDI with microfluidics and localized electroporation to temporally measure cellular responses. Bio-Integrated Electronics, Optoelectronics, Microfluidics and MEMS. Source: Northwestern University Adilson E. Motter is the Charles E. and Emma H. Morrison Professor of Physics and Astronomy at Northwestern University. Inspired by his undergraduate research experience, Cesar joined Prof. Horacio Espinosa's laboratory at Northwestern University to pursue a PhD degree in Mechanical Engineering. TY - CHAP. Ph.D. The student then receives a doctorate from the French institution and a PhD from Northwestern.. With advisors on both sides of the Atlantic and opportunities . Founded: 2017. PhD Student. Email address. In fiber optics, we developed and commercialized classes of devices that provide tunable operation for chromatic dispersion compensation for high-speed, wavelength-multiplexed lightwave communication systems. Our early work in microfluidic optical fiber helped to establish the field of optofluidics. PY - 2012/1/1 Credit: Northwestern University "Ice it . Evanston, IL 60208. The present global pandemic draws attention to the importance of rapid sample-to-answer PoC devices for . Recent work has focused on problems in microfluidics and soft matter theory. However, measuring reaction progression in these small devices is hindered by available readout methods, which typically rely on fluorescent products. Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, 60208 USA. Northwestern Undergraduate Research Journal; Items. panpanhuang2015@u.northwestern.edu. However, recording of time-dependent variations in sweat composition requires bulky electronic systems and power sources, thereby constraining form factor, cost, and modes of use. Northwestern Microfluidics Engineering and Maintenance Team Hunter Rogers, M.S. 2 School of Aeronautics, Northwestern Polytechnical University, 127 West Youyi Rd., Xi'an, Shaanxi, China and Queensland Micro- and . Follow Hunter on LinkedIn. Upon joining the Stoddart Group at Northwestern University as a Postdoctoral Fellow in January 2022, Ruihua will . . Rogers's soft, flexible device rests on the skin and is composed of an intricate array of tiny channels and . The dual PhD, or co-tutelle de thèse, is an ad hoc agreement that allows outstanding students with specific interests and needs to have their PhD dissertation supervised by faculty members from both Northwestern and a French university. As featured in The New York Times, Northwestern Engineering's John Rogers has developed a new microfluidic device that analyzes a person's sweat composition to provide real-time feedback on their health and fitness performance. This paper demonstrates a simple microfluidic device that incorporates a functionalized self-assembled monolayer to measure the rate constant for a chemical reaction. Email address. The sweat sensor channel resides in between the regions for electrochemical and colorimetric sensing. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Initially introduced in 2016, Rogers' microfluidic design has come a long way in the past year. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Her graduate research encompassed single-cell protein analysis based on microfluidics, on-chip electrocatalysis of two-dimensional materials, and single-crystal electrical transport of nanoclusters and Metal-Organic Frameworks. Machine shops and prototyping labs house equipment for the development of physical and electrical prototypes, with capabilities ranging from wood & hand tools to CNC and 3D-printed components. . 3D hybrid microfluidic and electronic systems in the form of extended, interconnected 4-by-4 double-floor helical arrays of 3D microvascular networks with . Catalog description The objective is to give students an introduction to the essential fluid mechanical concepts needed to work in some of the most contemporary areas of mechanical engineering: microfluidics, nanotechnology, nanoscale materials, MEMS, nano-biotechnology, etc. The systems were first deployed on triathletes and are now routinely used by Northwestern's swimming team. These findings can be used to create built-in control mechanisms, thereby facilitating the development . "We took the control that's provided by external systems and built it into the device's structure." The study was published today (Oct. 23) in the journal Nature. Wearable Technology. As such, I am a student in the Quantitative and Systems Biology master's program. Circular holes (diameter, 1 mm) serve as inlets in the base of . McCormick. The project involves using 3D endometrial ex vivo models to study the influence of a PCOS ovary in a microfluidic platform. . Analytics. Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. Discover the role of microfluidics and microfluidic technology in analytical chemistry. One such technology is normalizing and increasing the use s of microfluidic devices. Chicago . A Northwestern University research team has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise. September 2016. Search for more papers by this author. This work combines fundamental studies with forward-looking engineering efforts in a way that promotes positive feedback between the two. Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities . 633 Clark Street. Northwestern University Feinberg School of Medicine. Microfluidic biodisks take advantage of noninertial pumping for lab-on-a-chip devices using noninertial valves and switches under centrifugal and Coriolis forces to distribute fluids about the disks. Watch on. •We are working hard to serve micro/nano fabrication in research. Micro uidics is the science of manipulating uids on spatial scales anywhere between one to a hundred micron. Photo credit: H. Luan, Northwestern University. Photo credit: P. Gutruf, Northwestern University. The candidate will join a dynamic research team that has pioneered microfluidic technology for the study of reproductive tissues. Northwestern researchers' pain relief device is about 5 millimeters wide and as thin as a sheet of paper, flexible and soft enough to wrap around nerves without causing damage. Epicore Biosystems creates soft microfluidics devices that harvest and route sweat from skin pores. In January 2022, she joined the Stoddart Group at Northwestern University as a Postdoctoral Fellow. If you think you would be a good match with our lab, don't hesitate to contact Prof. Horacio D. Espinosa for more information at espinosa@northwestern.edu. Electroosmosis has important applications in microfluidics and nanotechnology. . Earlier designs measured chloride loss, glucose, lactate and pH levels in sweat. A Northwestern University research team has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise. Robert H. Lurie Comprehensive Cancer Center of Northwestern University Clinical Cancer Center. Theory of Stokes-flow. Fusce aliquam porta venenatis. BioCDs use spinning-disk interferometry, under the condition of common-path phase quadrature, to perform interferometric label-free detection of . Abstract Microfluidic laboratory-on-a-chip (LOC) systems based on a modular architecture are presented. The device is described as a soft, miniaturized, implantable nerve cooling system that is based on "state-of-the-art microfluidic and flexible electronic technologies." However, at very small scales (on the order of 100 microns and less) electrostatic forces at charged interfaces can actually drive fluid flow. . In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use. crs@northwestern.edu. Accessibility; Morbi semper sollicitudin placerat. 645 N. Michigan Ave., Suite 630 Chicago, IL 60611. The device won an innovation award at this year's CES convention in Las Vegas. Now Northwestern University researchers are pushing microfluidics closer to reaching its true potential. Danny Vesurai , Reporter . Galter Pavilion 675 N. St. Clair, 21st Floor Chicago, IL 60611. 15th International Conference on Miniaturized Systems for Chemistry and . Figure S8B and Fig. Evanston, IL 60208. Northwestern Resources. Northwestern University. . His current research focuses on the design and manufacturing of microfluidic devices to nondestructively extract molecules from live cells for analysis. His work has advanced the fields of microfluidics, BioMEMS, biomechanics, and cellular physiology through a combination of instrumentation, imaging, software, and computational modeling. I am particularly interested in problems in biology such as the interaction of biological membranes with fluid flow and electric fields. john a. kessler Northwestern Univeristy . Our most active areas are in neurotechnologies and in biomedical . The lab is available to students and faculty in support of their educational project work and is staffed by lab professionals and student lab leaders who are skilled in . Imaging Neurons with Microfluidic Chambers. I am particularly interested in problems in biology such as the interaction of biological membranes with fluid flow and electric fields. . publisher = "American Association for Clinical Chemistry Inc.", number = "2",} Delaney, SR & Suh-Lailam, BB 2018, ' Microfluidics: The future of testing? sweat) extraction, capture, and analysis in real time, outside of controlled laboratory environments. Northwestern University - Cited by 101 - Microfluidics - BioMEMS - Electroporation - Intracellular Delivery - Single Cell Analysis . 312-503-6303. . Managerial Analytics (KELLG_MA) Materials Science & Engineering (MAT_SCI) Math Methods in the Social Sciences (MMSS) Mathematics (MATH) Mechanical Engineering (MECH_ENG) Middle East and North African Studies (MENA) Music (MUSIC) Music Composition (MUS_COMP) Music Education (MUSIC_ED) A little larger than a quarter and about the same thickness, the simple . McCormick School of Engineering and Applied Science. Northwestern University crs@northwestern.edu. A Northwestern University-led team of researchers has developed a small, soft, flexible implant that relieves pain on demand and without the use of drugs. ', Clinical chemistry Clinical chemistry The device mixes the reactants and allows them to selectively immobilize to the monolayer at the base of a microfluidic channel in a time-dependent manner as they flow down the . Now Northwestern University researchers are pushing microfluidics closer to reaching its true potential. 866-LURIE-CC or 312-695-0990. Northwestern University is an Equal Opportunity, Affirmative Action Employer of all . Newer platforms also quantify concentrations of heavy metals such as lead and arsenic and urea and creatinine levels, the latter of which relates to kidney health. These two microfluidic structures flank either side of the patch. 5D highlight the multimodal microfluidic substrate and chrono-sampling features of the system. Roozbeh Ghaffari. Recent developments in skin-integrated soft microfluidic systems address many challenges associated with standard technologies in sweat collection and analysis. Candidate, Obstetrics & Gynecology, Northwestern University. Khvostichenko, DS, Perry, SL, Kondrashkina, E, Guha, S, Brister, K & Kenis, PJA 2011, Microfluidic platforms for on-chip formulation and small-angle X-ray analysis of the phase behavior of lipid/water mixtures. But the sheer size of the external equipment required for controlling these quarter-sized devices has limited their use in portable, wearable technologies. May 2021: Tad's article, "Ultrafast Spectroscopy of Plasmonic Titanium Nitride Nanoparticle Lattices," has been published in ACS Photonics. . Her graduate research encompassed single-cell protein analysis based on microfluidics, on-chip electrocatalysis of two-dimensional materials, and single-crystal electrical transport of nanoclusters and Metal-Organic Frameworks. Research: High-Throughput, Cell-Based Assays with SAMDI; Megamolecule-Based Imaging Agents and Therapeutics for Cancer and Alzheimer's Disease Eric is using SAMDI to evaluate large libraries of nanomaterials in order to discover design rules governing cancer vaccine efficacy.
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